Bronchial Brushings (bronchial + brushing)

Distribution by Scientific Domains

Selected Abstracts

Correlation between morphology and human telomerase gene amplification in bronchial brushing cells for the diagnosis of lung cancer

Yi-Bo Fan M.D.
Abstract The aim of this study was to investigate the frequency of amplification of the human telomerase gene (TERC), as measured by fluorescence in situ hybridization (FISH), in routine liquid-based cytological preparations from bronchial brushing specimens, and to assess the associations between TERC amplification, cytological diagnosis, and cytological morphology, in order to obtain further insight into these associations. Bronchial brushings from 102 patients with lung carcinoma (52 squamous-cell carcinomas, 22 adenocarcinomas, 28 small cell lung carcinomas) and 40 patients with nonmalignant disease were used. Amplification of TERC was performed using a commercially available two-color FISH probe, and slides were prepared for the SurePath liquid-based Pap test (LPT) using the same samples. Amplification of TERC was significantly associated with histological diagnoses (P < 0.05). Patients with lung cancer, and especially those with nonsmall cell lung cancer, had significantly higher percentages of cells with amplification of TERC than did patients with nonmalignant disease (P < 0.05). Comparing the FISH and LPT results, there was no significant difference in diagnostic sensitivity between the two methods (P > 0.05). However the difference in diagnostic sensitivity of the two methods for squamous-cell carcinoma was significant (P < 0.01). FISH can be performed on bronchial brushing specimens to detect amplification of TERC. This test may be an adjunct to cytology screening, especially in squamous-cell carcinoma, and may provide an indication of the potential of individual lesions to progress. Diagn. Cytopathol. 2010. 2009 Wiley-Liss, Inc. [source]

Simultaneous cytological diagnosis of herpes simplex virus infection and primary lung cancer: Report of two cases

Nicoletta Maounis M.D., Ph.D.
Abstract Herpes simplex is an uncommon cause of lower respiratory tract infection that requires prompt diagnosis and treatment to prevent late complications. We report two cases with simultaneous herpes simplex virus infection of the lower respiratory tract and lung carcinoma. Cytology of bronchial brushing and washing fluids and postbronchoscopic sputum established the diagnosis, which was further corroborated by real-time polymerase chain reaction. Diagn. Cytopathol. 2008;36:818,822. 2008 Wiley-Liss, Inc. [source]

Diagnostic value and cost-effectiveness of bronchial brushings in the diagnosis of bronchial malignancy

E. Youd
No abstract is available for this article. [source]

Reed-sternberg cells in bronchial brushings from a patient with Hodgkin's disease

Deepa Kasuganti M.D.
No abstract is available for this article. [source]